Depression is one disorder that can severely affect the quality of life and may lead to significant disability. Depression has a daunting 11% prevalence among US adults aged between 18 and 25 years. In 2016, 64% patients of depression reported severe impairment. Moreover, 67% patients needed medications and healthcare professional advice.
About this Infusion
Reasons to Infuse Ketamine
Ketamine has significant role in all the major treatment strategies for the management of resistant depression:
Is Ketamine IV Therapy safe?
In a 2010 study, depression 24 patients were given six repeated doses of Ketamine infusion and no side effects were reported. The patients remained symptom free for 28 days in that study. (5) Another report published in 2015 examined the safety and tolerability of Ketamine in 205 ketamine infusions and only 4 infusions were stopped due to side effects and even those side effects subsided after withdrawal of the infusion.
What is the Standard Operating Procedure for Ketamine Infusion Administration?
When the consensus report on Ketamine was published in March 2017, several experts in psychiatry and mental health expressed their opinions on it. On March 10, 2017, Dr. Brian Bailey (Psychiatry/Mental Health) had said that Ketamine is a neuromodulator and therefore, it aides psychotherapy. He further shared his experience, “Another reason that this central aspect of its (Ketamine) use does not receive the emphasis it deserves, is that it is so effective that some of its users become their own best therapists and don’t really need help”. (7) The major guiding points of the expert consensus report are outlined in the following bullets:
- Evaluate procedural requirements
- Obtain patient consent for infusion treatment
- Assess and document vital signs (BP, heart rate, oxygen saturation)
- Before starting the treatment ask for patient name one more time
- Reconfirm the Ketamine dosing parameters and correct any anomalies (if any)
- Diligently monitor the patient’s physiologic and mental status during the infusion treatment
- Best dosing schedule is “twice a week for four weeks” administration of .5 mg/kg infusion administered over a period of 45 minutes.
- Once clinical response is achieved, treatment should be stopped. (8)